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Research

Equipment

Instrumentation available at FABI

 

LC-MS

  • Waters Acquity UPLC I class system coupled to Xevo G2 Q-TOF mass spectrometer

HPLC/UHPLC instruments

  • Thermo Scientific ultrahigh pressure liquid chromatography (UHPLC) system with PDA detection
  • Shimadzu gradient ultrafast liquid chromatography (UFLC) system with PDA detection
  • Merck-Hitachi Lachrom Elite gradient HPLC system with PDA detection and ELSD detection (Alltech ELSD 2000)
  • Two Merck-Hitachi Lachrom gradient HPLC systems with UV detection

SFC instruments

  • UPC² (Waters): Supercritical fluid chromatography system with PDA detection
  • Thar Method station II: Supercritical fluid chromatography system with PDA detection

Capillary electrophoresis/Capillary electrochromatography

  • Capillary electrophoresis Agilent HP3DCE system with PDA detection
  • Two Capillary electrophoresis Beckman P/ACE MDQ systems with PDA detection (one also with LIF detection)
  • Unimicro-Trisep 2100 GV Pressurized capillary electrochromatography system with UV detection

Spectroscopy

  • Bran+Luebbe InfraAlyzer 500Near infrared spectrophotometer
  • Shimadzu UV-2101PC UV/Vis spectrophotometer

Miscellaneous

  • Ecocell 111 liter incubator
  • Sartorius Arium Pro UV ultrapure water system
  • Haskel DSHF-302-S High pressure liquid pump
  • Capillary burner EK 1.2, Capital HPLC
  • Harrick Plasma cleaner/sterilizer

Recent projects

Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB -CHARLES UNIVERSITY CZECH REPUB, RIASOVA , Petra

22/03/2019
OZR3383: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB -CHARLES UNIVERSITY CZECH REPUB, RIASOVA , Petra

Mangelings, D.

22/03/19 → 21/03/22

Project : Fundamental

Cofinancing OZR FWO Hercules MZW equipment: GHz-THz VNA measurement infrastructure: from benchtop to portable instruments serving advanced sensor solutions in a variety of multi-disciplinary application domains.

11/04/2018
OZR3251: Cofinancing OZR FWO Hercules MZW equipment: GHz-THz VNA measurement infrastructure: from benchtop to portable instruments serving advanced sensor solutions in a variety of multi-disciplinary application domains.

Stiens, J. , Peeters, E. , Maes, D. , Vander Heyden, Y. , Mangelings, D...

Modern chiral separation strategies: a tool to facilitate the development of QSRR models

07/02/2018
FWOKN305: Modern chiral separation strategies: a tool to facilitate the development of QSRR models

Mangelings, D. & Vander Heyden, Y.

1/01/18 → 31/12/18

Project : Fundamental

Development of a supercritical fluid chromatographic system to predict the skin permeability of pharmaceutical compounds.

22/09/2017
FWOTM851: Development of a supercritical fluid chromatographic system to predict the skin permeability of pharmaceutical compounds.

Vander Heyden, Y. , Mangelings, D. & Grooten, Y.

1/10/17 → 30/09/21

Project : Fundamental

VLIR UOS TEAM 2017 : Quality Control and Therapeutic Valorization of Moroccan Argan oils: the impact of the sustainability of the human development.

24/01/2017
VLIR345: VLIR UOS TEAM 2017 : Quality Control and Therapeutic Valorization of Moroccan Argan oils: the impact of the sustainability of the human development.

Vander Heyden, Y. , De Cupere, F. & Motmans, J.

1/01/17 → 31/08/22

Project :...

Topics

  • Chiral Separations, Monolithic stationary phases, Miniaturized separation techniques, Capillary Electrochromatography, High Performance Liquid Chromatography, Capillary Electrophoresis, Supercritical Fluid Chromatography, Experimental design (Debby Mangelings)
  • Method development and optimisation; Method validation (robustness testing); Separation techniques (e.g. HPLC, CE, CEC); Chemometrics in separation science, QSAR, QSRR and QSSR; Herbal fingerprints, Drug-impurity profiling, Chiral separations, Metabolomics (Yvan Vander Heyden)
  • Neuropeptides, Miniaturized UHPLC-ESI-MS/MS (Jana Bongaerts)
  • SFC and LC coupled with circular dichroism (CD) detector, Molecular Dynamics and Quantitative Structure Enantioselective Retention Relationship (QSERR) models (Pieter De Gauquier)
  • Skin permeability modelling in HPLC, Micellar liquid chromatography (Yasmine Grooten)
  • Computation and Medicinal Chemistry: Developing methods for Computer-Aided Drug Design (Jordy Peeters)
  • Chiral separation, Impurity determination, CE, SFC (Petra Riasova)
  • Chemometrics, Metabolomics, Classification and discrimination of chromatographic fingerprints, UPLC-ESI QTof MS (Karen Segers)